GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UVM | cis | rs2985684 | 1 | rs2224949 | chr14:50096560 | RPL36AL | chr14:50085407-50087349:- | -0.54 | -5.79 | 3.51E-7 | Carotid intima media thickness |
| UVM | cis | rs8078723 | 1 | rs2227336 | chr17:38174855 | GSDMA | chr17:38119226-38134019:+ | -0.87 | -7.55 | 4.73E-10 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| UVM | cis | rs2239557 | 1 | rs2239557 | chr14:74551970 | LIN52 | chr14:74551656-74667117:+ | 0.44 | 5.65 | 5.92E-7 | Common traits (Other) |
| UVM | cis | rs9876781 | 1 | rs2242150 | chr3:48505964 | TREX1 | chr3:48501186-48509043:+ | 0.49 | 5.44 | 1.27E-6 | Longevity |
| UVM | cis | rs2273 | 1 | rs2242471 | chr4:76878716 | NAAA | chr4:76831809-76862166:- | 0.46 | 5.35 | 1.77E-6 | Longevity |
| UVM | cis | rs2273 | 1 | rs2242473 | chr4:76878956 | NAAA | chr4:76831809-76862166:- | 0.46 | 5.33 | 1.89E-6 | Longevity |
| UVM | cis | rs2273 | 1 | rs2242474 | chr4:76878982 | NAAA | chr4:76831809-76862166:- | 0.46 | 5.35 | 1.77E-6 | Longevity |
| UVM | cis | rs8135828 | 1 | rs2247753 | chr22:30022936 | CABP7 | chr22:30116344-30127818:+ | 1.04 | 6.84 | 7.02E-9 | Lipid traits |
| UVM | cis | rs2564921 | 1 | rs2253209 | chr3:53115160 | RFT1 | chr3:53122503-53164470:- | -0.36 | -5.19 | 3.18E-6 | Height |
| UVM | cis | rs2564921 | 1 | rs2253656 | chr3:53119099 | RFT1 | chr3:53122503-53164470:- | -0.36 | -5.19 | 3.18E-6 | Height |
| UVM | cis | rs2564921 | 1 | rs2253685 | chr3:53119703 | RFT1 | chr3:53122503-53164470:- | -0.36 | -5.33 | 1.91E-6 | Height |
| UVM | cis | rs2564921 | 1 | rs2253796 | chr3:53120098 | RFT1 | chr3:53122503-53164470:- | -0.36 | -5.33 | 1.91E-6 | Height |
| UVM | cis | rs2273 | 1 | rs2273 | chr4:76889388 | NAAA | chr4:76831809-76862166:- | 0.46 | 5.35 | 1.77E-6 | Longevity |
| UVM | cis | rs11190604 | 1 | rs2273694 | chr10:102256496 | SEC31B | chr10:102246403-102289636:- | -0.39 | -5.1 | 4.38E-6 | Palmitoleic acid (16:1n-7) plasma levels |
| UVM | cis | rs11190604 | 1 | rs2273695 | chr10:102259568 | SEC31B | chr10:102246403-102289636:- | -0.39 | -5.1 | 4.38E-6 | Palmitoleic acid (16:1n-7) plasma levels |